These muscles revealed new functions for IAPs not required for viability: Focal Adhesion Kinase (FAK), RSU1, tensin and vinculin. For example, it was recently found that Gα13, a G-protein subunit (Section, binds integrin β3 in a mutually exclusive, but temporally regulated wave-like pattern to promote outside-in signaling (Shen et al., 2013). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Integrins are cell surface transmembrane glycoproteins that function as adhesion receptors in cell-ECM interactions and link matrix proteins to the cytoskeleton. Integrins play an important role in cytoskeleton organization and in the transduction of intracellular signals, regulating various process … 1995 Feb 10; 267 (5199):883–885. Integrin Signaling. Science. Integrin receptors are involved in cell adhesion, migration, survival, and growth. The integrin family in man ... which have been identified as integrin-binding proteins in yeast two-hybrid screens and which could mediate the coupling of integrins to intracellular signaling pathways. Erratum in Int J Dev Biol 2001 Sep;45(5-6):following 770. This protein complex increases the membrane affinity for Rac, leading to further activation of the kinase pathways mentioned above [2]. Integrin signaling often occurs in coordination with other receptors and pathways. Tarone G(1), Hirsch E, Brancaccio M, De Acetis M, Barberis L, Balzac F, Retta SF, Botta C, Altruda F, Silengo L. Author information: (1)Department of Genetics, Biology and Biochemistry, University of Torino, Italy. The name “integrin” was suggested for an integral membrane protein complex first characterized in 1986 (Tamkun et al. We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated. Another signaling pathway utilized by integrin for MAPK activation is via integrin association with caveolins. Caveolins are small membrane proteins (22 kD) that can associate to form high molecular mass proteins. This signaling is central in hematopoietic cell function, for example, at places of inflammation or infection, where integrins trigger a cascade by which leukocytes exit the vasculature. Integrin function and regulation in development. Morino N, Mimura T, Hamasaki K, Tobe K, Ueki K, Kikuchi K, Takehara K, Kadowaki T, Yazaki Y, Nojima Y. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2.