It all involves the application of Le Châtelier's Principle. This article is cited by It depends on what compound you're talking about. To increase the efficiency of those processes, the aqueous solubility of pharmaceutical cocrystals was predicted in this work using perturbed-chain statistical associating … Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. A novel approach for predicting the dissolution profiles of pharmaceutical tablets. J.C. Dearden, M.T.D. Files available from the ACS website may be downloaded for personal use only. Christian Krintel, Karla Frydenvang, Lars Olsen, Maria T. Kristensen, Oriol de Barrios, Peter Naur, Pierre Francotte, Bernard Pirotte, Michael Gajhede, Jette S. Kastrup. Hyun Kil Shin, Young-Mook Kang, Kyoung Tai No. Paulo S. Carvalho, Jr., Javier Ellena, Dmitry S. Yufit, and Judith A. K. Howard . Electronic Supporting Information files are available without a subscription to ACS Web Editions. Karolina Jagiello, Aleksandra Mostrag-Szlichtyng, Agnieszka Gajewicz, Toru Kawai, Yoshitaka Imaizumi, Takeo Sakurai, Hiroshi Yamamoto, Norihisa Tatarazako, Kaoruko Mizukawa, Yasunobu Aoki, Noriyuki Suzuki, Haruna Watanabe, Tomasz Puzyn. Sudhir Mittapalli, M. K. Chaitanya Mannava, Rasmita Sahoo. The best performing network for intrinsic solubility predictions has a cross-validated root mean square error (RMSE) of 0.70 log S-units, while the Marvin pKa plug-in has an RMSE of 0.71 pH-units. For example, the anion in many sparingly soluble salts is the conjugate base of a weak acid that may become protonated in solution. Solubility measurements of crystalline β-Ni(OH)2 in aqueous solution as a function of temperature and pH. 1% phenobarbital will precipitate at or below a pH of 8.3) Sungjin Kim, Adrián Jinich, and Alán Aspuru-Guzik . Wajid Rehman, Sirajul Haq, Bakhtiar Muhammad, Syed Fahad Hassan, Amin Badshah, Muhammad Waseem, Fazal Rahim, Obaid-ur-Rahman Abid, Farzana Latif Ansari, Umer Rashid. Linda Lange, Kristin Lehmkemper, and Gabriele Sadowski . Solubility of Pharmaceuticals and Their Salts As a Function of pH, Laboratory of Thermodynamics, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge Straße 70, D-44227 Dortmund, Germany. Maryam Salahinejad, Tu C. Le, and David A. Winkler . Cronin, K.L.E. The model parameters of the nonionized pharmaceuticals were determined from their solubilities in pure organic solvents (acetone, ethanol, 2-propanol, n-hexane, n-heptane, and toluene), which were also measured. Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. Martin Lucke, Iraj Koudous, Maximilian Sixt, Maximilian J. Huter, Jochen Strube. O. Yongmin Zhang, Fei Qin, Xuefeng Liu, Yun Fang. Ajit S. Narang, Sherif Badawy, Qingmei Ye, Dhaval Patel, Maria Vincent, Krishnaswamy Raghavan, Yande Huang, Aaron Yamniuk, Balvinder Vig, John Crison, George Derbin, Yan Xu, Antonio Ramirez, Michael Galella, Frank A. Rinaldi. Find more information about Crossref citation counts. Angela Effinger, Caitriona M. O’Driscoll, Mark McAllister, Nikoletta Fotaki. Determination and Correlation of Solubility of Cephradine and Cefprozil Monohydrate in Water As a Function of pH. Many sparingly soluble compounds have solubilities that depend on pH. Yidong Yang, Ola Engkvist, Antonio Llinàs, and Hongming Chen . Structure-Directing Agents for the Synthesis of TiO2-Based Drug-Delivery Systems. Prediction of the solubility of selected pharmaceuticals in water and alcohols with a group contribution method. Synthesis, in vitro potential and computational studies on 2-amino-1, 4-dihydropyrimidines as multitarget antibacterial ligands. Muhammad Jawad Ahmad, Syed Fahad Hassan, Riffat Un Nisa, Khurshid Ayub, Muhammad Shahid Nadeem, Samina Nazir, Farzana Latif Ansari, Naveeda Akhtar Qureshi, Umer Rashid. Beyond Size, Ionization State, and Lipophilicity: Influence of Molecular Topology on Absorption, Distribution, Metabolism, Excretion, and Toxicity for Druglike Compounds. Multiple dissociation constants of the Intepirdine hydrochloride using regression of multiwavelength spectrophotometric pH-titration data. 63, In Honor of Rudi van Eldik's 65th Birthday, pp. Thomas Reschke, Kseniya V. Zherikova, Sergey P. Verevkin, Christoph Held. These metrics are regularly updated to reflect usage leading up to the last few days. Advanced Drug Delivery Reviews 59: 546-567. Measurement and ANN prediction of pH-dependent solubility of nitrogen-heterocyclic compounds.