If this effect lasts or gets worse, tell your doctor or pharmacist promptly. Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue; signs of gout such as … Adverse Reactions: In NEXLETOL clinical trials, the most commonly reported adverse reactions were … Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Call your doctor if you have any of the following … Medscape - Hyperlipidemia dosing for Nexletol (bempedoic acid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Avoid NEXLETOL and NEXLIZET in patients who have a history of tendon disorders or tendon rupture. Serious side effects include tendon rupture. In company-funded studies, common Nexletol side effects included high blood pressure and muscle and joint pain. NEXLETOL can cause side effects that can become serious, including: high levels of uric acid in the blood, which can lead to gout, a painful joint condition. Nexletol Side Effects Abdominal pain may occur.