7 Several statins are metabolized through the CYP450 system (TABLE 1). Drug-Dependent: The risk of statin-associated myopathy has been shown to increase as a patient’s statin dose increases. Another theory is that statin… How statins cause muscle pain is not fully understood. So, if your pain is localized to only one area of your body, then it’s probably related to something else. Which statin has the least side effects? Co-Q10 helps some people. Myalgia: Muscle pain which is experienced by 2% to 10% of people taking statins. So, if your pain is localized to only one area of your body, then it’s probably related to something else. In general, muscle symptoms directly due to a statin drug cause diffuse muscle aches. In a Cochrane Foundation Analysis of 37,939 individuals involved in nine clinical trials, 9.4% of those receiving statins experienced myalgia, a rate MONDAY, June 3 (HealthDay News) -- People taking statin drugs to lower their cholesterol may slightly increase their risk for muscle and joint diseases … 6,9,20-26 Therefore, drugs that). Statin-related muscle problems are more likely to occur in people who exercise vigorously, especially if they begin to do so at a rapid rate rather than slowly building up intensity. I would like to know if anyone is taking something that comes with less side effects. Other statins might not cause the muscle aches -- pravastatin and fluvastatin are least likely to have these side effects, and I would recommend those if a person really needed to be on a statin. It is also more common in people taking a variety of other medications, including Lopid (gemfibrozil), as well as steroids, cyclosporine, or niacin. One theory is that statins may affect a protein in muscle cells, which decreases muscle growth. Speak to your doctor if you have muscle pain, tenderness or weakness that cannot be explained – for example, pain that is not caused by physical work. My husband is having a problem with extreme fatigue, muscle pain, and severe tinnitus since starting a statin, rosuvastatin, a couple of weeks ago. Statins can occasionally cause muscle inflammation (swelling) and damage.