After five years of high-dose Lipitor, the average LDL had fallen to 77 mg/dL compared with 101 mg/dl in the low-dose Lipitor group. Don’t double your dose. Primary objective was to compare the effects of atorvastatin 40 mg vs 80 mg on LDL-C in Indian patients with atherosclerotic dyslipidemia. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. These plans provide the same coverage as…. Your doctor may perform a baseline liver function test (an initial liver function test that is repeated in a few months). This information is not a substitute for medical advice. What is Caprylic/Capric Triglyceride and Is It Safe? However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. Simvastatin oral tablet is available as the brand-name drug Zocor. The follow up period was 6 months. In those serious cases, treatment is needed to help clear up the infection. These drugs are often used to treat similar conditions. Use the pictures above to identify your dose. Be sure to avoid doing this when the weather is very hot or very cold. The good news is that you can reduce this with diet and exercise..it does work, been there, done it, wearing the T-shirt. Pink eye in babies is common but can sometimes be more serious. Usual Adult Dose for Prevention of Cardiovascular Disease Initial dose: 10 mg or 20 mg orally once a day -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. Other drugs that increase risk of myopathy or rhabdomyolysis include: Digoxin is used to treat heart failure and arrhythmias. These drugs should not be used with simvastatin. Take simvastatin in the evening to maximize its effects. Cardiovascular health among youths still has…, In a pair of articles published today in the New England Journal of Medicine, researchers tout the potential of bempedoic acid as a powerful new tool…, As far as natural alternatives to chemical ingredients go, capric acid and caprylic triglyceride is one of the cleanest ingredients that you can find…. Dosing rosuvastatin at 80 mg exceeds the manufacturer's maximum daily dose and is not approved by the US Food and Drug Administration (FDA). Store the tablets between 41°F and 86°F (5°C to 30°C). When flying, never put it into a checked bag. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. In some cases, they may not be available in every strength or form as the brand-name drug. Some may be better suited for you than others. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Don’t worry about airport x-ray machines. Statins work to reduce the body’s cholesterol production. See statins in Asian patients for more. If you don’t take it at all or stop taking it: If you have high cholesterol and don’t take your simvastatin, you risk having increased cholesterol levels, developing heart disease, and having a heart attack or a stroke. Always speak with your doctor or pharmacist about dosages that are right for you. High cholesterol. They won’t damage your medication. This information is not a substitute for medical advice. They also reduce the amount of cholesterol and triglycerides moving through the body. Statins are a class of drugs that lower LDL, or “bad,” cholesterol levels in the body by preventing production in the liver, where the majority of the…. Although none of our patient had significant elevation of CPK. This study concluded that both doses of atorvastatin (40 & 80 mg) are equally efficacious in improving dyslipidemia but higher dose leads to more incidence of myalgia. Disclaimer: Our goal is to provide you with the most relevant and current information. All rights reserved. You can take simvastatin with or without food. This study was conducted on 240 patients of dyslipidemia (as per ACC/AHA 2013 lipid guidelines) attending the OPD/wards/CCU of department of cardiology, Sir Ganga Ram Hospital. This can lead to an increased risk of bleeding. These drugs block your body from breaking down simvastatin. However, because drugs affect each person differently, we can not guarantee that this list includes all possible dosages. Avoid grapefruit juice while taking simvastatin. Objectives: To study whether high-dose versus usual-dose statin treatment reduces the incidence of peripheral artery disease (PAD) and what is the effect of high-dose statin treatment on cardiovascular disease (CVD) outcome in patients with PAD. Always discuss possible side effects with a healthcare provider who knows your medical history. Studies Find New Drug May Help Lower Cholesterol. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. Having hypothyroidism or diabetes raises your risk for this condition. Your doctor will write the number of refills authorized on your prescription. My moms cholesterol level is much higher then mine and she is on 20mg simvastatin tabs. It comes in two forms: a tablet and a suspension. Statin Dose Intensity and Equivalency Chart*. However, the dosage may range from 5 mg to 40 mg per day. Tell your doctor right away if you experience: Simvastatin is a prescription drug. The comparison between two doses revealed a non-significant difference (p = .118 & p = .149 respectively). This can be harmful or prevent the drug from working well. This can lead to very high levels of the drug in your body. They may also do additional liver and kidney function tests during treatment. Taking simvastatin with digoxin can increase levels of digoxin in your body. Starting: 10 - 20 mg once daily in the evening; Maintenance: 5 - 40 mg once daily; Max: 40 mg once daily; Asian patients: simvastatin may increase risk of myopathy. A class of drugs is a group of medications that work in a similar way. Examples of these drugs include: With niacin, the risk of myopathy and rhabdomyolysis is higher when the drug is taken in larger doses, and in people of Chinese descent. Disclaimer: Our goal is to provide you with the most relevant and current information. If you’re pregnant and need treatment for high cholesterol or triglycerides, talk to your doctor. Don’t put this medication in your car’s glove compartment or leave it in the car. At 3 and 6 month follow up, Atorvastatin 40 mg leads to mean LDL cholesterol reduction of 47.18 ± 20.81 & 50.03 ± 18.06 respectively. A prescription for this medication is refillable. Simvastatin blocks the production of cholesterol, which is important for the developing baby. Your doctor monitor your warfarin level more closely if you’re taking these two drugs at the same time. Using simvastatin with colchicine can increase the risk of both myopathy and rhabdomyolysis.